Targeted Optical Imaging of Colonic Tumors

Jun 19, 04:38 AM

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Deane et al. from Vanderbilt University (Nashville. TN) reported in the April issue of Molecular Cancer Research (2007;5:34l-349) on the development of a high-throughput in vivo imaging approach to detect spontaneously arising colonie tumors in mice using a novel peripheral benzodiazepine receptor (PBRMargeted molecular imaging agent. NIR-conPK11195 is a transmitochondrial membrane protein that modulates steroid biosynthesis. In experiments with Smad3 (-/-) mice, the tracer localized in coIonic adenomas and carcinomas, which were detected with a sensitivity of 67% and specificity of 86% 13 hours after injection. Moreover, the tracer was not retained in nonneoplastic hamartomas or chronically inflamed colonie tissue. The authors concluded that these results indicate that "NIRconPK 11195 is a promising optical molecular imaging tool to rapidly screen for colonie tumors in mice and to discriminate inflammation from cancer." Molecular Cancer Research

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