SPECT Imaging of Viral Biodistribution

Jun 19, 04:38 AM

Current Headlines: By Anonymous

In an article e-published on April 5 ahead of print in Gene Therapy, Raty et al. from the AI Virtanen Institute for Molecular Sciences and Ark Therapeutics (Kuopio, Finland) reported on microSPECT imaging of the biodistribution of a ^sup 99m^Tc-DTPA- biotin-labeled avidin-displaying baculovirus in a rat model. Virus injection was through 4 different routes, and imaging results suggested that although the virus spread via the lymphatic network after all routes, that localization and accumulation varied by administrative route. Specific results led the authors to conclude that "the baculovirus may be beneficial for the treatment of kidney diseases" via the intraperitoneal route. The study is 1 example of the ways in which molecular imaging of viruses is providing essential information about biodistribution for the development of targeted gene therapy vectors. Gene Therapy

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