Transgenics and Cloning

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• Science: Biology: Genetics: Eukaryotic: Animal: Transgenics and Cloning  (16)

Animal Models Core Facility - - University of North Carolina at Chapel Hill. The Facility makes animal models of human disease for medical researchers by creating genetically modified mice. Transgenic and gene-targeted animals are generated from DNA constructs provided by clients.

BCM Mouse Genome Project - - Large scale ENU based mouse mutagenesis for developmental defect.

Boston University Knock Out Mouse Core Facility - - Offers transgenic mouse services for the Boston University medical campus.

BUMC: Transgenic Mice Core - - The mouse core facility at Boston University School of Medicine provides centralized, expert service to produce successfully transgenic as well as knock out mice for investigators at Boston University and as an outside service.

caMOD: Cancer Models Database - - Searchable database for animal models of cancer.

The Cancer Center at Washington University (St. Louis) - ES Core - - The Embryonic Stem Cell Core has been created to help create mutations in murine embryonic stem cells. The core has several missions, including development of state-of-the-art reagents for the production of targeted mutations in embryonic stem cells, the creation of quality-controlled embryonic stem cell lines, and the teaching of methods for embryonic stem cell culture and manipulation.

The Case Transgenic and Targeting Facility - - Provide transgenic, targeting, targeted point mutations, chimera, rederivation and cryopreservation services for the Cleveland Biomedical Research Community. Includes mouse breeding FAQs, costs, and protocols.

CGDN Transgenic Core Facility - - The CGDN Core Facility offers investigators with efficiency and quality in transgenic and knock-out mouse technologies.

CMHD ENU Mutagenesis - - Centre for Modeling Human Disease (CMHD) use genome-wide ENU based random mutagenesis in mice to discover new genes and create new mouse models.

Cre-lox Plasmids - - Cre-lox DNA recombination is used extensively for designing transgenic/knockout mice. This site provides short descriptions and technical information for various Cre-lox DNA vectors and links to relevant resources.

Cre-X-Mice: A Database of Cre Transgenic Lines - - A database, maintained by Dr. Nagy's laboratory at Mount Sinai Hospital, of Cre transgenic mouse lines.

Deltagen and Lexicon Knockout Mice - - A database of select mutant mice and frozen embryo stocks created and characterized by Deltagen Incorporated and Lexicon Genetics Incorporated. Available for use without restrictions for academic and not-for-profit institutions.

Gene Targeting and Transgenic Facility - - GTTF, at the University of Virginia, produces and preserves genetically engineered mouse strains for animal model research.

German Gene Trap Consortium (GGTC) - - The German Genetrap Consortium (GGTC) generates a reference library of gene trap sequence tags (GTST) from insertional mutations generated in mouse embryonic stem (ES) cells.

Harwell Mutagenesis Programme - - A large scale mouse genetics programme to identify new phenotypes of relevance to human disease through ENU mutagenesis.

Herbert Irving Comprehensive Cancer Center :Transgenic Mouse Facility - - The Facility produces transgenic mice by microinjecting investigator-provided DNA into fertilized mouse eggs and chimeric mice by microinjecting embryonic stem (ES) cells into mouse blastocysts.

In Celebration of Dr. Mario R. Capecchi's Nobel Prize - - Article from the International Journal of Biological Sciences on Dr. Capecchi who received the Nobel Prize in Physiology or Medicine in 2007 for the discoveries of principles to introduce specific gene modifications in mice using embryonic stem cells.

International Mouse Strain Resource - - IMSR is a searchable online database of mouse strains and stocks available worldwide, including inbred, mutant, and genetically engineered mice.

John Curtin School, ANU : Gene Targeting Laboratory Research, - - Gene targeting laboratory at The John Curtin School of medical research, Australian National University.

KUMC :Transgenic and Gene-targeting Institutional Facility - - The Transgenic and Gene-targeting Institutional Facility (TGIF) at the University of Kansas Medical Center (KUMC) provides a centralized facility for production of transgenic mice.

MCDB Transgenic Facility - - Provides a barrier environment for the housing of valuable strains of mice and a core facility for use in the generation of transgenic mice. University of Colorado, Boulder.

McLaughlin Research Institute - - Not-for-profit mouse mutagenesis program.

Medical College of Wisconsin : Transgenic Core Facility - - Services include transgenic mouse production by microinjection of oocytes, gene targeting in ES cells, generation of ES cell chimeras, and embryo cryopreservation.

MMRRC: Mutant Mouse Regional Resource centers - - A repository of mouse stocks and ES cell line collections serving the world-wide genetics and biomedical research community for the benefit of human health.

Mount Sinai School of Medicine: Mouse Genetics Shared Research Facility - - The institutional Mouse Genetics Research Facility has been established to provide the Mount Sinai research community with access to state-of-the-art facilities for the production of transgenic and knockout mice.

Mouse Genome Informatics - - MGI (A Jackson laboratory resource) provides integrated access to data on the genetics, genomics, and biology of the laboratory mouse.

Mouse Genotyping Services - - Biotechnology company providing affordable mouse genotyping services with no set up fees and quick turn around.

Mouse Phenome Database - - MPD (A Jackson laboratory resource) provides a collection of phenotypic and genotypic data for the laboratory mouse.

ORNL Mutant Mouse Database - - Collection of several hundred mouse stocks, most of which propagate mutations induced by radiations or chemicals in various stages of male or female gametogenesis.

Purdue University Transgenic Mouse Core Facility - - Serves as a centralized resource for the production of transgenic and gene-targeted mice for Purdue investigators.

Riken Large Scale Mutagenesis Program - - A large scale mouse ENU mutagenesis project at Riken GSC, Japan.

SUNY-Stony Brook Transgenic Mouse Facility - - Consult and conduct transgenic (pronuclear DNA injection) and gene-targeting projects in mice.

Tennessee Mouse Genome Consortium - - The Consortium's purpose is to promote mouse models for human genetic diseases and as subjects for the study of gene function.

Transgenic Animal Colony at Your Fingertips - - Provides comprehensive, configurable software for transgenic animal facilities of any scale.

Transgenic Animal Service of Queensland - - Service run by the University of Queensland's Institute for Molecular Biosciences which provides transgenic mice and other related services for Australian Science.

Transgenic Animal Web - - Links to useful transgenic resource.

Transgenic Core Facility - - Produces transgenic and knockout mice for the researchers at St. Jude Children's Research Hospital (SJCRH).

Transgenic Models of Skin Disease Core at Harvard - - At the Harvard Skin Disease Research Center. Mainly provides services for the generation of mouse skin disease models.

Transgenic Mouse / Embryonic Stem Cell Shared Resource - - Provides transgenic or gene knockout mice. At the Vanderbilt-Ingram Cancer Center.

Transgenic Mouse Facility - - This facility at UC Irvine provides services on a recharge basis for making, breeding, genotyping, importing and preserving genetically-modified mice.

Trans-NIH Mouse Initiative - - This site will provide information on: follow-up meetings to the initial March meeting; funding opportunities for mouse genomics and genetics resources; major resources-producing grants funded in response to the initiative; progress toward meeting the goals of the initiative; major mouse genomics and genetics resources; courses and scientific meetings related to the mouse initiative; and selected reports and publications.

Tufts University School of Medicine, Transgenic Core Facility - - Fee-for-service facility providing pronuclear microinjection for the production of standard transgenic mice, blastocyst injections for the production of knockout and knock-in mice, rederivation services and embryo cryopreservation.

UC-Davis Transgenic Mouse Research - - Transgenic histopathology laboratory at the University of California-Davis providing comprehensive light and electron microscopic analysis of tissues submitted by interested investigators .

UC-Irvine Transgenic Mouse Facility - - Home Page of the Transgenic Mouse Facility at UC-Irvine. The TMF is a core facility serving the UCI community, other UC campuses, and outside collaborators of UC researchers.

UCSD Transgenic Mouse Core - - The Transgenic Mouse and Embryonic Stem Cell Gene Targeting Core is a state-of-the-art facility that has an outstanding track record in the production of genetically altered mice.

UF Shands Cancer Center-Transgenic Mouse Core Facility - - University of Florida Shands Cancer Center. Transgenic Mouse Core Facility.

UM SCCC --Gene Knockout and Transgene Facility - - The University of Miami Transgenic and Targeted Mutant Mouse Core Facility is subsidized by the Sylvester Comprehensive Cancer Center. The primary objective of the facility is to efficiently produce transgenic mice and targeted-mutant mic.

UMass Medical School:Transgenic Knockout Animal Core Facility - - The mission of the Transgenic-Knockout Animal Core Facility is to produce genetically-altered mice for the UMASS Medical School Community.

University of Kentucky Transgenic Facility - - The facility provides state-of-the-art equipment and expertise essential for producing transgenics and maintains a mouse colony.

University of Michigan Transgenic Animal Model Core - - The Transgenic Core routinely prepares transgenic mice and mice with targeted mutations for University of Michigan investigators.

University of Missouri-Columbia Transgenic Animal Core - - University of Missouri-Columbia Transgenic Animal Cor.

University of Texas Health Science Centre at Houston - - The Laboratory for Developmental Biology is a shared service support facility of the Institute in which embryonic stem cell lines, knock-out mice and transgenic mice are being produced.

Upenn Transgenic and Chimeric Mouse Facility - - Provides a centralized service to efficiently produce transgenic mice for basic research. At the University of Pennyslyvania.

UTMB Transgenic Mouse Facility - - This state-of-the art facility, supported by the Sealy Center for Cancer Cell Biology, is available for use by all UTMB scientists.

Wadsworth Center -Transgenics and Gene Knockout - - Transgenics and Gene Knockout - Wadsworth Center Core Facilities, New York State Department of Health.

Yale Transgenic Mouse and Gene Targeting Resource - - Produces transgenic and knock out mice for cancer center members and members of the Yale community.

University of Hawaii - - News release that was reported in the journal nature concerning the first reproducible cloning of mammals from adult cells. (July 22, 1998)